Harrison was born on August 20, 1833, in North Bend, Ohio; he grew up on a farm located near the Ohio River below Cincinnati. His father, John Harrison, was a farmer, and his grandfather, William Henry Harrison, was elected as the ninth president of the United States in 1840, but died of pneumonia only one month after he took office. Benjamin Harrison graduated from Miami University in Oxford, Ohio, in 1852 and married Caroline Lavinia Scott the following year; the couple would go on to have two children. After studying law in Cincinnati, Harrison moved to Indianapolis, Indiana, in 1854 and set up his own law practice.

Though his father had warned Benjamin of the pressures of a life in politics, his wife encouraged his political ambitions. The young Harrison became active in state politics in Indiana, joining the fledgling Republican Party, which had been built on the opposition to slavery and its extension into the western territories. He supported the first Republican presidential candidate, John C. Frémont, in 1856 and Abraham Lincoln in 1860. When the Civil War broke out in 1861, Harrison joined the Union Army as a lieutenant in the 70th Indiana Volunteer Infantry Regiment, and he would attain the rank of brevet brigadier general by 1865.

Back in Indiana after the war’s end, Harrison resumed his law practice and political activity, campaigning unsuccessfully for the Republican gubernatorial nomination in 1872. Four years later, he won the nomination but lost a close race in the general election.

From 1881 to 1887, Harrison represented Indiana in the U.S. Senate, arguing for the rights of homesteaders and Native Americans against the expanding railroad industry and campaigning for generous pensions for Civil War veterans, among other issues. A highly principled and devoutly religious man, Harrison broke with the Republican Party to oppose the Chinese Exclusion Act of 1882 (which aimed to close the United States to Chinese immigrants) due to its violation of rights given to the Chinese under an earlier treaty; the act passed without his support.

Harrison lost his Senate seat after a Democratic victory in the Indiana state legislature in 1887, only to gain the Republican nomination for president the following year. Rather than travel around the country during the campaign, he gave numerous speeches to delegations that visited him in Indianapolis–an early example of so-called “front-porch campaigning.” In a controversial general election, Harrison lost the popular vote to the incumbent President Grover Cleveland by 90,000 votes but carried the electoral college, gaining 233 electoral votes to Cleveland’s 168 thanks to victories in the key swing states of New York and Indiana (where Harrison’s opponents later suggested that his campaign had purchased votes in order to win).

During Harrison’s term in the White House, the lingering effects of an economic depression led to calls for more expansive federal legislation. A longtime protectionist, Harrison supported the passage of the McKinley Tariff Act of 1890 (backed by the Ohio congressman and future president William McKinley). For the first time in peacetime, Congress appropriated a billion dollars during Harrison’s administration, angering many Americans who saw the president and his fellow Republicans as too supportive of wealthy interests.

On the other hand, Harrison lent his support to the Sherman Silver Purchase Act, which required the government to purchase 4.5 million ounces of silver per month, and bowed to the pressure of agrarians and reformers by signing into law the Sherman Antitrust Act, designed to prohibit industrial combinations or trusts. (Ohio Senator John Sherman sponsored both acts.) Harrison also continued his support of veterans’ benefits as well as his advocacy of forest conservation and the expansion of the U.S. Navy.

In the foreign policy arena, Harrison’s administration (including the president and secretary of state, James G. Blaine) displayed a growing American influence in world affairs. The First International Conference of American States (later the Pan-American Union) took place in Washington, D.C. in late 1889. In addition, Harrison’s State Department successfully negotiated with Germany and Great Britain to set terms for an American protectorate in the Samoan Islands and opposed Britain and Canada in order to prevent the overharvesting of seals in the Bering Sea. Harrison was unsuccessful, however, in his attempts to convince Congress to back the construction of a canal in Nicaragua, as well as in his efforts to annex Hawaii in 1893.

Up for reelection in 1892, Harrison struggled to overcome growing populist discontent, including a number of labor strikes. In the general election, he faced Grover Cleveland again, along with a third-party challenge from the Populist, or People’s, Party. The revelation that Caroline Harrison was seriously ill led to modest campaign efforts by both men and caused Harrison to limit his appearances in key swing states, contributing to the margin of his defeat. Caroline died of tuberculosis in late October, and two weeks later Harrison lost to Cleveland by an electoral vote of 145 to 277, the most decisive victory in 20 years.

After leaving the White House, Harrison returned to Indianapolis and his law practice. At the age of 62, he married Mary Lord Dimmick, his late wife’s niece and caretaker; they had one child. In 1898, Harrison served as leading counsel for Venezuela in the arbitration of its boundary dispute with Great Britain. After spending almost a decade as a respected elder statesman and acclaimed public speaker, he died in 1901 of pneumonia.